ORIGINAL ARTICLE

Phytochemical screening and evaluation of cytotoxic activity of Pandanus fascicularis L. (Fruits)

K.M. Rahat Maruf Jitu, Dipti Debnath , Sharmeen Asad, Rajib Chandra Das, Abida Sultana

K.M. Rahat Maruf Jitu
Department of Pharmacy, Noakhali Science and Technology University, Bangladesh

Dipti Debnath
Department of Pharmacy, Atish Dipankar University of Science and Technology, Bangladesh. Email: diptidebnath@rocketmail.com

Sharmeen Asad
Department of Pharmacy, State University of Bangladesh, Dhaka-1205, Bangladesh.

Rajib Chandra Das
Department of Applied Chemistry and Chemical Engineering, Noakhali Science and Technology University, Banglades

Abida Sultana
Department of Applied Chemistry and Chemical Engineering, Noakhali Science and Technology University, Bangladesh.
Online First: July 15, 2017 | Cite this Article
Jitu, K., Debnath, D., Asad, S., Das, R., Sultana, A. 2017. Phytochemical screening and evaluation of cytotoxic activity of Pandanus fascicularis L. (Fruits). Discovery Phytomedicine 4(3): 31-34. DOI:10.15562/phytomedicine.2017.43


The present study was conducted to evaluate possible phytochemicals present, and cytoctoxic activity of extract of fruits of Pandanus fascicularis L. Phytochemical screening was carried out using the standard test methods of different chemical group. Evaluation of cytotoxic activity was done using the brine shrimp lethality bioassay. The aqueous, methanolic, ethanolic, ethyl acetate, pet ether and chloroform extracts show presence of maximum phytochemicals such as alkaloids, tannins, flavonoids, steroids, saponins, proteins, terpens, phenols, glycosides, carbohydrate in different fractions etc. During cytotoxicity test, the positive control groups showed nonlinear mortality rates at lower concentrations and linear rates at higher concentrations. The LC50 values of Chloroform extract was found 1.0636 µg/ml where the positive control vincristine sulphate showed LC50 at a concentration of 0.200µg/ml. Therefore, the plant extract possess potent cytotoxic effect.
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