ORIGINAL ARTICLE

Evaluation of in vivo analgesic, antiemetic and anxiolytic effect of methanolic extract of Litsea monopetala in animal model

Abdullah Al Mahmud

Abdullah Al Mahmud
. Email: noory.chemistry@gmail.com
Online First: July 15, 2019 | Cite this Article
Mahmud, A. 2019. Evaluation of in vivo analgesic, antiemetic and anxiolytic effect of methanolic extract of Litsea monopetala in animal model. Discovery Phytomedicine 6(3). DOI:10.15562/phytomedicine.2019.102


Objective: The present study was conducted to investigate in vivo analgesic, antiemetic and anxiolytic effect of methanolic extract of Litsea monopetala in animal model.

Materials and Methods:  Analgesic activity was performed by formalin induce method .The antiemetic activity was conducted by using chick animal model where mean decrease in number of retches were calculated and anxiolytic activity was done by using Elevated Plus Maze(EPM) and Hole board method.

Results: The methanolic extract of Litsea monopetala at a dose of 400 mg/kg exhibited statistically significant(P<0.05) and produced  66.67%  of inhibition of paw licking in mice where standard drug showed 50 % inhibition. The extract further showed dose dependent and statistically(P<0.05) significant antiemetic activity at a dose of 200 mg/kg and 400 mg/kg respectively. In addition the extract has showed excellent CNS depressant activity in both Elevated Plus Maze(EPM) and Hole board method in compare to standard drug diazepam.

Conclusion: From our current study it is obvious that the extract has good analgesic, antiemetic and anxiolytic effect which may be due to the presence of  different chemical constituents like terpenes ,  flavonoids, tannins, saponin and sterols.

 

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