Macaranga barteri stem bark extract exerts anti-inflammatory and anti-hyperalgesia activity in murine models

Evelyn Asante-Kwatia , Yakubu Jibira, Abraham Yeboah Mensah, Debora Osei-Sarfoh

Evelyn Asante-Kwatia
Kwame Nkrumah University of Science and Technology. Email: eamireku@knust.edu.gh

Yakubu Jibira
Kwame Nkrumah University of Science and Technology

Abraham Yeboah Mensah
Kwame Nkrumah University of Science and Technology

Debora Osei-Sarfoh
Kwame Nkrumah University of Science and Technology
Online First: July 15, 2019 | Cite this Article
Asante-Kwatia, E., Jibira, Y., Mensah, A., Osei-Sarfoh, D. 2019. Macaranga barteri stem bark extract exerts anti-inflammatory and anti-hyperalgesia activity in murine models. Discovery Phytomedicine 6(3). DOI:10.15562/phytomedicine.2019.104

This study was undertaken to evaluate the anti-inflammatory, anti-hyperalgesia and antioxidant activity of the hydro-alcoholic stem bark extract of Macaranga barteri (MBE). The carrageenan-induced foot oedema and Hargreaves thermal hyperalgesia models in rats were used to examine the anti-inflammatory and anti-hyperalgesic effects respectively. The 2, 2-diphenyl-2-picrylhydrazyl hydrate (DPPH) free radical scavenging and total antioxidant capacity assays were used to determine the antioxidant activity. In a curative protocol, MBE (30, 100, 300 mg kg-1, p.o.) dose dependently and significantly inhibited carrageenan-induced foot oedema by 37.01 ± 13.08, 53.01 ± 9.87 and 64.11 ± 9.05% respectively (ED50 = 89.37 ± 7.52 mg kg-1). The extract further attenuated cutaneous hyperalgesia by prolonging paw withdrawal latencies towards an external heat stimulus with an ED50 of 105.5 ± 4.22 mg kg-1. MBE was found to possess a total antioxidant capacity of 531.62 ± 10.98 mg g-1 dry weight (Gallic acid equivalent) and scavenged DPPH free radicals with an IC50 of 19.45 ± 1.46 µg/mL. The results provide the first report on the anti-inflammatory, analgesic and antioxidant activity of M. barteri stem bark and partly justify its traditional use in the management of inflammation and pain. This could be attributed to phytochemicals such as tannins, terpenoids, sterols, coumarins and flavonoids which were identified in preliminary phytochemical studies of the stem bark.


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