ORIGINAL ARTICLE

Experimental analysis of isolated compounds of Borreria hispida (L) in the context of antioxidant.

Abu Montakim Tareq , Saifuddin Farhad, Sajal Chakraborty

Abu Montakim Tareq
Department of Pharmacy, International Islamic University Chittagong, Kumira, Chittagong-4318, Bangladesh. Email: montakim0.abu@gmail.com

Saifuddin Farhad
Department of Pharmacy, International Islamic University Chittagong, Kumira, Chittagong-4318, Bangladesh

Sajal Chakraborty
Department of Pharmacy, BGC Trust University Bangladesh, Chittagong-4381, Bangladesh
Online First: September 05, 2019 | Cite this Article
Tareq, A., Farhad, S., Chakraborty, S. 2019. Experimental analysis of isolated compounds of Borreria hispida (L) in the context of antioxidant.. Discovery Phytomedicine 6(3). DOI:10.15562/phytomedicine.2019.107


Borreria hispida comprises an effective potential source of natural antioxidant, which might be helpful in preventing the progress of various oxidative stresses. This study aimed to gain information by molecular docking of biologically active compounds of Borreria hispida with Glutathione reductase (GR), Urate oxidase(UO), Protein-tyrosine kinase 2-β (PTK-2β) and Peroxiredoxin-5(PRDX5) proteins target that are responsible for antioxidant activity and also correlate the relation by previous literature in vitro antioxidant analysis. Molecular docking analysis of the compounds was done by Schrodinger. Furthermore ADME properties of the isolated compounds were evaluated with QikProp. A mixed range of docking score was found during molecular docking by Schrodinger where the in vitro study showed moderate antioxidant activity. They also satisfy the Lipinski rule to sow the drug-like properties. Due to its superior docking score, it could be an effective GR, UO, PTK-2β and PRDX5 inhibitors. Furthermore studies are required to detect GR, UO, PTK-2β and PRDX5 inhibitory activity of isolated compounds from Borreria hispida

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