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Experimental analysis of isolated compounds of Borreria hispida (L) in the context of antioxidant.



Abstract

Borreria hispida comprises an effective potential source of natural antioxidant, which might be helpful in preventing the progress of various oxidative stresses. This study aimed to gain information by molecular docking of biologically active compounds of Borreria hispida with Glutathione reductase (GR), Urate oxidase(UO), Protein-tyrosine kinase 2-β (PTK-2β) and Peroxiredoxin-5(PRDX5) proteins target that are responsible for antioxidant activity and also correlate the relation by previous literature in vitro antioxidant analysis. Molecular docking analysis of the compounds was done by Schrodinger. Furthermore ADME properties of the isolated compounds were evaluated with QikProp. A mixed range of docking score was found during molecular docking by Schrodinger where the in vitro study showed moderate antioxidant activity. They also satisfy the Lipinski rule to sow the drug-like properties. Due to its superior docking score, it could be an effective GR, UO, PTK-2β and PRDX5 inhibitors. Furthermore studies are required to detect GR, UO, PTK-2β and PRDX5 inhibitory activity of isolated compounds from Borreria hispida
Keywords: Borreria hispida Antioxidant activity Molecular docking ADME.

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How to Cite

Tareq, A. M., Farhad, S., & Chakraborty, S. (2019). Experimental analysis of isolated compounds of Borreria hispida (L) in the context of antioxidant. Discovery Phytomedicine - Journal of Natural Products Research and Ethnopharmacology, 6(3). https://doi.org/10.15562/phytomedicine.2019.107
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