Effect of Asparagus racemosus on selected female reproductive parameters using Wistar rat model.

Linet Mwende Kaaria

Linet Mwende Kaaria
University of Nairobi. Email: linetmwee@gmail.com
Online First: October 15, 2019 | Cite this Article
Kaaria, L. 2019. Effect of Asparagus racemosus on selected female reproductive parameters using Wistar rat model.. Discovery Phytomedicine 6(4). DOI:10.15562/phytomedicine.2019.110

Dysmenorrhea is a major cause of female morbidity globally. Asparagus racemosus (ASP) is traditionally used to manage dysmenorrhea in Nakuru, Kenya. This study evaluates the effect of Asparagus racemosus on female reproductive parameters; estrus cyclicity, mating success, gestation length, litter size and dysmenorrhea. The effect of Asparagus racemosus and ibuprofen on isolated uterine strips was evaluated using six non-pregnant rats. The uterine strips were exposed to serial extract concentrations (20, 40, 80,160 mg/ml) and 20 mg/ml ibuprofen was used as a positive control.

There was significant increase of proestrus phase (P < 0.001) and a subsequent significant reduction in the metestrus (P < 0.01) and diestrus (P < 0.05). No significant difference in mating success and gestation length, however Ibuprofen caused significant disruption of gestation length (P < 0.05).  The treated groups produced higher number of pups compared to controls. The plant extract caused a dose dependent significant reduction in uterine force of contraction by (-0.15%, -5.13%, -7.97%, -19.55 %) at 20, 40, 80 and 160 mg/ml respectively. The plant extract also caused a significant decline in frequency of uterine contraction (-5.99%; -9.61%; -16.76% and -25.21%) The extract caused no mortality even at the limit dose; 5000 mg/kg. Asparagus racemosus reduces uterine force and frequency of contraction. This is probably the reason for its traditional use in dysmenorrhea management.



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