Background: Medicinal plants are the major sources of traditional treatment of disease and new drug discovery due to major side effects of synthetic drug. Objectives: The aim of study was to evaluate analgesic and antioxidant activities of petroleum ether and chloroform soluble fractions of whole plant extract of Acanthus ilicifoius. Materials and Methods: The plant extract, standard diclofenac, and distilled water as control was administered post orally in Swiss albino mice and observe the analgesic activity by acetic acid (0.6%) induced writhing method. The plant extract was also subjected to perform reducing power assay, DPPH free radical scavenging activity, and FRAP assay to evaluate antioxidant activity. Results: The pet ether, and chloroform soluble fraction of plant extract revealed significant analgesic activity on mice model. Notably, the pet ether and chloroform fraction showed (40.14 Â± 2.32) % and (40.12 Â± 0.9) % analgesic inhibition, whereas standard diclofenac revealed (52.79 Â± 2.62) % analgesic inhibition. In antioxidant activity assay, the plant extract showed mild to moderate antioxidant activities compare to standard ascorbic acid. Conclusion: From the results, it could be concluded that, the pet ether and chloroform fractions of whole plant extract of A. ilicifolius possesses potential analgesic and antioxidant properties.
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How to Cite
Faisal, M. A. R., Barek, M. A., Jahan, S., Shahid-Ud-Daula, A. F. M., Basher, M. A., & Hasanuzzaman, M. (2020). Petroleum Ether and Chloroform Soluble Fractions of Whole Plant Extract of Acanthus ilicifolis Linn. Possesses Potential Analgesic and Antioxidant Activities. Discovery Phytomedicine - Journal of Natural Products Research and Ethnopharmacology, 7(1), 12–18. https://doi.org/10.15562/phytomedicine.2020.113