ORIGINAL ARTICLE

Petroleum Ether and Chloroform Soluble Fractions of Whole Plant Extract of Acanthus ilicifolis Linn. Possesses Potential Analgesic and Antioxidant Activities.

Md. Abu Rayhan Faisal, Md. Abdul Barek, Sharmin Jahan, A. F. M. Shahid-Ud-Daula, Mohammad Anwarul Basher, Md. Hasanuzzaman

Md. Abu Rayhan Faisal
Noakhali Science and Technology University

Md. Abdul Barek
Noakhali Science and Technology University

Sharmin Jahan
Noakhali Science and Technology University

A. F. M. Shahid-Ud-Daula
Noakhali Science and Technology University

Mohammad Anwarul Basher
Noakhali Science and Technology University

Md. Hasanuzzaman
Noakhali Science and Technology University, Bangladesh. Email: hasanprdu@gmail.com
Online First: January 15, 2020 | Cite this Article
Faisal, M., Barek, M., Jahan, S., Shahid-Ud-Daula, A., Basher, M., Hasanuzzaman, M. 2020. Petroleum Ether and Chloroform Soluble Fractions of Whole Plant Extract of Acanthus ilicifolis Linn. Possesses Potential Analgesic and Antioxidant Activities.. Discovery Phytomedicine 7(1): 12-18. DOI:10.15562/phytomedicine.2020.113


Background: Medicinal plants are the major sources of traditional treatment of disease and new drug discovery due to major side effects of synthetic drug. Objectives: The aim of study was to evaluate analgesic and antioxidant activities of petroleum ether and chloroform soluble fractions of whole plant extract of Acanthus ilicifoius. Materials and Methods: The plant extract, standard diclofenac, and distilled water as control was administered post orally in Swiss albino mice and observe the analgesic activity by acetic acid (0.6%) induced writhing method. The plant extract was also subjected to perform reducing power assay, DPPH free radical scavenging activity, and FRAP assay to evaluate antioxidant activity. Results: The pet ether, and chloroform soluble fraction of plant extract revealed significant analgesic activity on mice model. Notably, the pet ether and chloroform fraction showed (40.14 ± 2.32) % and (40.12 ± 0.9) % analgesic inhibition, whereas standard diclofenac revealed (52.79 ± 2.62) % analgesic inhibition. In antioxidant activity assay, the plant extract showed mild to moderate antioxidant activities compare to standard ascorbic acid. Conclusion: From the results, it could be concluded that, the pet ether and chloroform fractions of whole plant extract of A. ilicifolius possesses potential analgesic and antioxidant properties.

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