Evaluation of anthelmintic, antioxidant and anti-inflammatory potential of methanolic extract of Artocarpus lacucha leaves

Md. Giash Uddin , Md. Monirul Islam, Arman Ahmed, Shafayet Ahmed Siddiqui, Aparna Debnath

Md. Giash Uddin
Department of Pharmacy, University of Chittagong, Chittagong-4331, Bangladesh. Email: giash.uddin@cu.ac.bd

Md. Monirul Islam
Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh.

Arman Ahmed
Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh.

Shafayet Ahmed Siddiqui
Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh.

Aparna Debnath
Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh.
Online First: January 15, 2020 | Cite this Article
Uddin, M., Islam, M., Ahmed, A., Siddiqui, S., Debnath, A. 2020. Evaluation of anthelmintic, antioxidant and anti-inflammatory potential of methanolic extract of Artocarpus lacucha leaves. Discovery Phytomedicine 7(1): 27-32. DOI:10.15562/phytomedicine.2020.115

Artocarpus lacucha is a medicinal plant of Moraceae family and conventionally used in diverse disorder. Investigation and design of this study was carried out to evaluate its antioxidant, anthelmintic and anti-inflammatory activity with methanolic extract of Artocarpus lacucha leaves. Thrombolytic activity was evaluated by using Perthima posthuma. For antioxidant potential total phenolic content and DPPH free radical scavenging activity test were conducted. Hypnotic solution and heat induced hemolysis was evaluated for anti-inflammatory activity. The methanolic extract of Artocarpus lacucha showed a significant anthelmintic activity in dose dependent manner that was comparable with that of standard drugs albendazole (10 mg/ml). Five different concentrations (10, 20, 30, 40 and 50 mg/ml) were used, whereas the albendazole drug at 10 mg/ml used as standard. The total phenolic content of the methanolic extract was found 74.4±0.291 while compared with gallic acid as standard. The IC50 value for the DPPH test was found 26.95±0.009. It indicates plant extract showed moderate antioxidant property. In case of membrane stabilizing assay, the methanolic extract (10 mg/ml) showed maximum effect with a value of 15.06 and 20.16% inhibition of hemolysis caused by hypotonic solution and heat respectively. On the other hand standard acetyl salicylic acid (0.10 mg/ml) revealed 53.71 and 56.32% inhibition of hemolysis induced by hypotonic solution and heat correspondingly. These pharmacological activities showed that the methanolic extract has potential anthelmintic, antioxidant and anti-inflammatory activity. Further research would help to reveal all its potency for safer new drugs in medical science.




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