ORIGINAL ARTICLE

Cytotoxic naphthoquinones from Diospyros fleuryana leaves

Son Ninh The , Ha Nguyen Thi Thu, Cuong Pham Van, Tra Nguyen Thanh, Tuyen Nguyen Van, Tu Anh Le Thi, Cham Ba Thi

Son Ninh The
. Email: yamantson@gmail.com

Ha Nguyen Thi Thu


Cuong Pham Van


Tra Nguyen Thanh


Tuyen Nguyen Van


Tu Anh Le Thi


Cham Ba Thi

Online First: January 15, 2020 | Cite this Article
Ninh The, S., Nguyen Thi Thu, H., Pham Van, C., Nguyen Thanh, T., Nguyen Van, T., Le Thi, T., Ba Thi, C. 2020. Cytotoxic naphthoquinones from Diospyros fleuryana leaves. Discovery Phytomedicine 7(1): 42-46. DOI:10.15562/phytomedicine.2020.117


In the search for anti-cancer plants in Vietnam, the leaves of Diospyros fleuryana were selected for chemical investigation. Phytochemical analysis of the ethyl acetate (EtOAc) extract led to the isolation of two naphthoquinones isodiospyrin (1), and 8'-hydroxyisodiospyrin (2), and one isoflavone 7-O-methylbiochanin A (3). The chemical structures of isolated compounds were determined by 1D-NMR (1H, and 13C-NMR), 2D-NMR spectra (HSQC, and HMBC), and MS spectroscopy. Compound 3 was isolated from genus Diospyros for the first time. Regarding the strong IC50 values of 2.27, and 8.0 µM against KB, and Hep cell lines respectively, cytotoxic examination suggested that compound 2 is a promising agent in anti-cancer treatment. 

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