In the past few years several developments in medications have been made for the better treatment of certain diseases like Breast Cancer, Alzheimerâ€™s disease, Tuberculosis, Obesity and Malaria. Phytochemicals possessing various medicinal properties have opened up the door to discover or design novel drug against these diseases. Syringic acid is such a natural compound found in many plants with a vast range of therapeutic potentials against several diseases. The present study aims to reveal Syringic acid as a potent inhibitor against Breast Cancer, Alzheimerâ€™s disease, Tuberculosis, Obesity and Malaria comparing to the standard drugs of each disease. Molecular docking of syringic acid with critical proteins associated with the diseases was done using SchrÃ¶dinger Maestro (v11.1). QikProp module of SchrÃ¶dinger Maestro was used for ADME prediction and the toxicity of the ligand was evaluated by ProTox online databases. Syringic acid was found to exhibit acceptable ADME properties with no carcinogenicity and mutagenicity. Molecular docking result also showed higher scores compared to the commercially available standard drugs against four out of five diseases. The best docking scores were found against Breast cancer, Alzheimerâ€™s disease, Obesity and Malaria which are -6.801 kcal/mol, -5.285 kcal/mol, -5.491 kcal/mol and -4.141 kcal/mol respectively. Syringic acid can be a stronger inhibitory potential agent against selected diseases than the standard drugs. Further clinical studies are required to consider syringic acid as an effective candidate drug for the better treatment of the mentioned diseases.