ORIGINAL ARTICLE

Anti-fertility properties of Cissus rotundifolia (Forssk.) Vahl. Extract using female Wistar rats

Anita Mary Mziray

Anita Mary Mziray
Egerton University, Njoro,kenya. Email: anitamziray14@gmail.com
Online First: April 25, 2020 | Cite this Article
Mziray, A. 2020. Anti-fertility properties of Cissus rotundifolia (Forssk.) Vahl. Extract using female Wistar rats. Discovery Phytomedicine 7(2). DOI:10.15562/phytomedicine.2020.120


A third of the worldwide disease burden among women in their reproductive age ( 15-45 years) is associated with sexual and reproductive complications. The developing world experiences an unmet contraceptive demand that affects nearly 200 million women. The high rates of unintended pregnancies in sub-Saharan Africa increase the prevalence of unsafe abortions in nations. The use of conventional steroids and non-steroid based contraceptives though effective is also linked to increasing side effects. The roots decoction of Cissus rotundifolia is used by women in Tana River County, Kenya as a fertility regulator. The study evaluated the phytochemical compounds present in the Cissus rotundifolia aqueous extract. It also evaluated the effect of the plant extract on oestrus cycle and other selected female reproductive parameters; mating success, fertility index, gestation length, and litter size using female Wistar rats. The phytochemical screening established the presence of alkaloids, tannins, saponins, phenols, and glycosides in the root aqueous extract of Cissus rotundifolia. The plant extract caused a dose-dependent significance increase in proestrus and metestrus phases and a significant reduction in estrus and diestrus phases (P<0.05). There was no significant difference in mating success. It caused a dose-dependent reduction in fertility index compared to the control. Gestation length was significantly increased and litter size significantly reduced (P<0.05).This probably is the reason for the traditional use of the plant as a fertility regulator. However, further work on reversibility, reproductive hormonal profile and ovarian histomorphology should be undertaken to improve the novel contraceptive pool.

 

No Supplementary Material available for this article.
Article Views      : 0
PDF Downloads : 0

Related Articles

Search Authors in












  • Anita Mary Mziray

  • Anita Mary Mziray

  • Anita Mary Mziray