Plant-mediated synthesis is gaining acceptance in many fields i.e. biology and pharmaceutical fields. This aim of this study is synthesizing Ag nanoparticles using air-dried leaves of two (2) neglected vegetables i.e.Â Celosia trigyna and Solanum nigrum.Â Ultravioletâ€“visible spectroscopy, fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM) were used to characterize the formation of silver nanoparticles (AgNPs). The anti-inflammatory properties of these AgNPs were evaluated using Cell Stabilization Membrane (CSM) and lipoxidase assays, their antioxidant activity were established on DPPH and ABTS+ assays. The positive control employed are indomethacin and ascorbic acid for these activities. Nanoparticles synthesized were labelled for Celosia trigyna (CT-AgNPs) and Solanum nigrum (SN-AgNPs) were noticed through visual color change. The UVâ€“Vis spectra of the synthesized nanoparticles displayed absorption bands at around 360-440 nm, which is a characteristic band for Ag and FTIR displayed possible functional groups responsible for Ag nanoparticles synthesized by these plants.Â The SEM image of the AgNPs formed displayed were spherical in morphology. CT-AgNPs exhibited the most significant inhibitory activity against HRBC (IC50: 32.2 Âµg/ml) while SN-AgNPs displayed the most significant inhibitory activity against lipoxygenases (IC50: 32.8 Âµg/ml) when compared to the positive control used indomethacin (IC50: 28.1 Âµg/ml). SN-AgNPs exhibited the most significant antioxidant effect against ABTS (IC50: 11.4 Âµg/ml) while CT-AgNPs displayed the most significant antioxidant activity against DPPH (IC50: 4.6 Âµg/ml) when compared to the positive control used ascorbic acid (IC50: 4.7 Âµg/ml). This work showed that the synthesized AgNPs from non-cultivated vegetable can find relevance and application in health, drugs, food and environmental science.