ORIGINAL ARTICLE

A pharmacological study on Stixis suaveolens (Roxb.) using experimental animal model

Shammi Akhter

Shammi Akhter
. Email: noory.chemistry@gmail.com
Online First: January 15, 2021 | Cite this Article
Akhter, S. 2021. A pharmacological study on Stixis suaveolens (Roxb.) using experimental animal model. Discovery Phytomedicine 8(1). DOI:10.15562/phytomedicine.2021.153


The présent study was aimed to screen crude methanol fruit extract of S. suaveolens for biological activity in mice model. The central analgesic activity was assessed using the ‘tail flick’ method. Whereas the peripheral analgesic activity was determined by acetyl salicylic acid induced writhing method. The anti-hyperglycemic potential was evaluated by the ability of the crude extract in reducing blood glucose level after oral glucose administration. The CNS stimulating activity was evaluated by the well-known phenobarbitone induced sleep bioassay. In ‘tail flick’ bioassay, the oral dose of crude extract resulted in 238% delay (P<0.001) in response time, comparable to the effect of standard morphine but its effect lasted till 90 min after administration, whereas morphine had a greater duration of action. The crude extract at 400 mg/kg showed significant (P<0.001) inhibition of writhing similar to the standard diclofenac (50 mg/kg). Maximum reduction of glucose level (39.6%) was observed 120 min after oral intake of the extract while the result was lower compared to the 46.83% reduction by the standard glibenclamide. Significant (p<0.01) reduction in time for onset of sleeping as well as the total sleeping time was recorded in mice receiving the crude extract. The extract resulted in delayed sleeping intervals by 156.4 min (91.6 min in control group) and the duration of sleep was reduced to 83.6 min while 148.4 min was recorded in the control. The in vivo bioassays confirms that the extract from the fruit of S. suaveolens possess significant analgesic (acting both centrally and peripherally), glucose lowering and CNS stimulating ability which has been the reason behind its popularity as a traditional medicine.

 

References

Raju GS, Moghal MMR, Dewan SMR, Amin MN, Billah MM. Characterization of phytoconstituents and evaluation of total phenolic content, anthelmintic, and antimicrobial activities of Solanum violaceum Ortega. Avicenna Journal of Phytomedicine. 2013, 3(4): 313-320.

Baul S, Amin MN, Hussain MS, Mukul MEH, Millat MS, Rashed MSU et al. Phytochemical Nature and Pharmacological Evaluation of Chloroform Extract of Pandanus fascicularis L. (Fruits) An in vivo Study. Journal of Bioanalysis & Biomedicine 2017, 9(4): 223-228.

Dewan SMR, Amin MN, Adnan T, Uddin SMN, ShahidUd-Daula AFM, Sarwar G et al. Investigation of analgesic potential and in vitro antioxidant activity of two plants of Asteraceae family growing in Bangladesh. Journal of Pharmacy Research. 2013, 6(6): 599-603.

Uddin SMN, Amin MN, Shahid-Ud-Daula AFM, Hossain H, Haque MM, Rahman MS. Phytochemical screening and study of antioxidant and analgesic potentials of ethanolic extract of Stephania japonica Linn. Journal of Medicinal Plant Resrearch, 2014; 8(37): 1127-1133.

Amin MN, Dewan SMR, Noor W, Shahid-Ud-Daula AFM. Characterization of chemical groups and determination of total phenolic content and in-vitro antioxidant Activities of ethanolic extract of Ocimum sanctum leaves growing in Bangladesh. European Journal of Experimental Biology, 2013; 3(1): 449-454.

Amin MN, Banik S, Ibrahim M, Moghal MMR, Majumder MS, Siddika R. A Study on Ardisia solanacea for Evaluation of Phytochemical and Pharmacological Properties. International Journal of Pharmacognosy and Phytochemical Research 2015; 7(1); 8-15.

Tanna MTH, Amin MN, Ibrahim M, Mukul MEH, Kabir A. Evaluation of antioxidants, membrane stabilizing, cytotoxic and anthelmintic activity with phytochemical screening of Chromolaena odorata: A medicinal shrub. International Journal of Pharmacy, 2016, 6(1):53-61.

Amin MN, Siddiqui SA, Uddin MG, Ibrahim M, Uddin SM et al. Increased Oxidative Stress, Altered Trace Elements, and Macro-Minerals Are Associated with Female Obesity. Biol Trace Elem Res, 2020, 197:384–393.

Amin MN, Hussain MS, Sarwar MS, Rahman Moghal MM, Das A, Hossain MZ, et al.

How the association between obesity and inflammation may lead to insulin resistance and cancer. Diabetes Metab Syndr. 2019; 13(2):1213-1224.

Tarequl Islam , Md Saddam Hussain, Mohammad Nurul Amin, Ashraful Mahmud Tuhin. Evaluation of psychopharmacological and neurosafety profile of Swas Kas Chintamani Ras (SKC) in Swiss-Webster mice. Avicenna J Phytomedicine, 2018; 8(1):85-95.

Amin MN, Liza KF, Sarwar MS, Ahmed J, Adnan MT, Chowdhury MI. et al. Effect of lipid peroxidation, antioxidants, macro minerals and trace elements on eczema. Arch Dermatol Res, 2015; 307(7):617-23.

Ghosh A, Banik S, Amin MN, Ahmed J. Evaluation of antinociceptive, antihyperglycemic, and membrane stabilizing activities of Garcinia lancifolia Roxb. J Tradit Complement Med., 2018 ;8(2):303-307.

Muktadir MHA, Islam MA, Amin MN, Ghosh S, Siddiqui SA, Debnath D. Nutrition transition - Pattern IV: Leads Bangladeshi youth to the increasing prevalence of overweight and obesity. Diabetes Metab Syndr., 2019; 13(3):1943-1947.

Islam MA, Amin MN, Siddiqui SA, Hossain MP, Sultana F, Kabir MR. Trans fatty acids and lipid profile: A serious risk factor to cardiovascular disease, cancer and diabetes.

Diabetes Metab Syndr., 2019; 13(2):1643-1647.

Baul S, Amin MN, Hussain MS, Mukul MEH, Millat MS, Rashed MSU et al. Phytochemical Nature and Pharmacological Evaluation of Chloroform Extract of Pandanus fascicularis L. (Fruits) An in vivo Study. Journal of Bioanalysis & Biomedicine 2017, 9(4): 223-228.

Uddin SMN, Amin MN, Shahid-Ud-Daula AFM, Hossain H, Haque MM, Rahman MS. Phytochemical screening and study of antioxidant and analgesic potentials of ethanolic extract of Stephania japonica Linn. Journal of Medicinal Plant Resrearch, 2014; 8(37): 1127-1133.

Amin MN, Dewan SMR, Noor W, Shahid-Ud-Daula AFM. Characterization of chemical groups and determination of total phenolic content and in-vitro antioxidant Activities of ethanolic extract of Ocimum sanctum leaves growing in Bangladesh. European Journal of Experimental Biology, 2013; 3(1): 449-454.

Amin MN, Banik S, Ibrahim M, Moghal MMR, Majumder MS, Siddika R. A Study on Ardisia solanacea for Evaluation of Phytochemical and Pharmacological Properties. International Journal of Pharmacognosy and Phytochemical Research 2015; 7(1); 8-15.

Raju GS, Moghal MMR, Dewan SMR, Amin MN, Billah MM. Characterization of phytoconstituents and evaluation of total phenolic content, anthelmintic, and antimicrobial activities of Solanum violaceum Ortega. Avicenna Journal of Phytomedicine. 2013, 3(4): 313-320.

Tanna MTH, Amin MN, Ibrahim M, Mukul MEH, Kabir A. Evaluation of antioxidants, membrane stabilizing, cytotoxic and anthelmintic activity with phytochemical screening of Chromolaena odorata: A medicinal shrub. International Journal of Pharmacy, 2016, 6(1): 53-61.

Raju GS, Moghal MMR, Dewan SMR, Amin MN, Billah MM. Characterization of phytoconstituents and evaluation of total phenolic content, anthelmintic, and antimicrobial activities of Solanum violaceum Ortega. Avicenna Journal of Phytomedicine. 2013, 3(4): 313-320.

Raju GS, Moghal MMR, Dewan SMR, Amin MN, Billah MM. Characterization of phytoconstituents and evaluation of total phenolic content, anthelmintic, and antimicrobial activities of Solanum violaceum Ortega. Avicenna Journal of Phytomedicine. 2013, 3(4): 313-320.

Su JX, Wang W, Zhang LB, Chen ZD. Phylogenetic placement of two enigmatic genera, Borthwickia and Stixis, based on molecular and pollen data, and the description of a new family of Brassicales, Borthwickiaceae. Taxon, 2006; 61(3): 601-611.

Reddy ARK, Grace JR. In vitro Evaluation of Antioxidant Activity of Brugeiera Gymnorrhiza and Aegialitis Rotundifolia. Med Aromat Plants. 2016; 5:231.

Sikder, M. A. A., Kaisar, M. A., Rashid, M. A., Millat, M. S., & Sultana, A. (2012). In vitro membrane stabilizing activity, total phenolic content, cytotoxic, thrombolytic and antimicrobial activities of Calliandrasurinamensis (Wall.). J. Pharmacog. Phytochem, 1(3), 45-50.

Škerget, M., Kotnik, P., Hadolin, M., Hraš, A. R., Simonič, M., &Knez, Ž. (2005). Phenols, proanthocyanidins, flavones and flavonols in some plant materials and their antioxidant activities. Food chemistry, 89(2), 191-198.

Rahaman, M.Z., Akhter, S., Islam, M.R., Begum, S., Mondal, K.K., Mottakin, M., Hossain, M.S., Bayen, S., Das, M. 2020. Assessment of thrombolytic, antioxidant and analgesic properties of a medicinal plant of Asteraceae family growing in Bangladesh. Discovery Phytomedicine 7(1): 47-52.


No Supplementary Material available for this article.
Article Views      : 0
PDF Downloads : 0

Related Articles

Search Authors in












  • Shammi Akhter

  • Shammi Akhter

  • Shammi Akhter