The prÃ©sent study was aimed to screen crude methanol fruit extract of S. suaveolens for biological activity in mice model. The central analgesic activity was assessed using the â€˜tail flickâ€™ method. Whereas the peripheral analgesic activity was determined by acetyl salicylic acid induced writhing method. The anti-hyperglycemic potential was evaluated by the ability of the crude extract in reducing blood glucose level after oral glucose administration. The CNS stimulating activity was evaluated by the well-known phenobarbitone induced sleep bioassay. In â€˜tail flickâ€™ bioassay, the oral dose of crude extract resulted in 238% delay (P<0.001) in response time, comparable to the effect of standard morphine but its effect lasted till 90 min after administration, whereas morphine had a greater duration of action. The crude extract at 400 mg/kg showed significant (P<0.001) inhibition of writhing similar to the standard diclofenac (50 mg/kg). Maximum reduction of glucose level (39.6%) was observed 120 min after oral intake of the extract while the result was lower compared to the 46.83% reduction by the standard glibenclamide. Significant (p<0.01) reduction in time for onset of sleeping as well as the total sleeping time was recorded in mice receiving the crude extract. The extract resulted in delayed sleeping intervals by 156.4 min (91.6 min in control group) and the duration of sleep was reduced to 83.6 min while 148.4 min was recorded in the control. The in vivo bioassays confirms that the extract from the fruit of S. suaveolens possess significant analgesic (acting both centrally and peripherally), glucose lowering and CNS stimulating ability which has been the reason behind its popularity as a traditional medicine.