ORIGINAL ARTICLE

Chemical constituents from the leaves of Styrax argentifolius H.L. Li and their antioxidative activity

Tra Nguyen Thanh, Cuong Pham Van, Ha Nguyen Thi Thu, Tu Anh Le, Son Ninh The

Tra Nguyen Thanh


Cuong Pham Van


Ha Nguyen Thi Thu


Tu Anh Le


Son Ninh The
. Email: yamantson@gmail.com
Online First: April 15, 2021 | Cite this Article
Nguyen Thanh, T., Pham Van, C., Nguyen Thi Thu, H., Le, T., Ninh The, S. 2021. Chemical constituents from the leaves of Styrax argentifolius H.L. Li and their antioxidative activity. Discovery Phytomedicine 8(2). DOI:10.15562/phytomedicine.2021.160


Searching for bioactive agents from medicinal plants, the phytochemical investigation on the EtOAc extract of the Vietnamese Styrax argentifolius leaves has resulted in the isolation and structural determination of five compounds, including one nor-neolignan egonoic acid (1), one lignan (+)-pinoresinol (2), one sterol (20R)-3β-hydroxysitgmasta-5,22-dien-7-one (3), and two triterpenoids lupeol (4), and 2α,3α,24-trihydroxy-urs-12-en-28-oic acid (5). The chemical structures of these secondary metabolites were elucidated by NMR and MS spectral data. All isolated compounds were first observed in S. argentifolius species. Sterol 3 and triterpenoid 5 were detected in genus Styrax for the first time. With the IC50 value of 19.10 µg/mL, compound 2 possessed the strong activity in DPPH radical scavenging assay.

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