Bioactivity validation of Phyllanthus amarus using cell lines as model systems

Koto-te-Nyiwa Ngbolua; Pius Mpiana; Virima Mudogo; Ashande Colette Masengo; Clovis Ndege; Dorothee Tshilanda; Damien Tshibangu

doi:10.15562/phytomedicine.2015.29

Bioactivity validation of Phyllanthus amarus using cell lines as model systems

Koto-te-Nyiwa Ngbolua ,

Pius Mpiana ,

Virima Mudogo ,

Ashande Colette Masengo ,

Clovis Ndege ,

Dorothee Tshilanda ,

Damien Tshibangu ,

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DOI: https://doi.org/10.15562/phytomedicine.2015.29 |
Published: 2015-10-15

Abstract

Medicinal plants constitute an important component of flora and are widely distributed in the Democratic Republic of the Congo (DRC). The aim of the present study was to validate scientifically both the anti-malarial effectiveness and safety of Phyllanthus amarus a medicinal plant traditionally used to treat malaria in DRC using standardized model systems. Ethanolic crude extracts of P. amarus were evaluated for the inhibitory effects on two malaria parasites strains (P. falciparum FcM29 & P. yoelii subsp nigeriensis) while cytotoxicity of the plant extract was carried out against leukaemia P-388 cell lines. Results indicate that, P. amarus displayed good activity both in vitro and in vivo. While the crude extract displayed toxic effect towards P-388 cells. So, the wide use of this medicinal plant in Congolese Folk Medicine as anti-malarial herbal could constitutes a great risk of population poisoning. From this study, it can be predicted that P. amarus possess secondary metabolites with considerable cytotoxic potency and could lead to the discovery of useful anti-cancer drugs of plant origin.

Bioactivity validation of Phyllanthus amarus using cell lines as model systems

Abstract

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