Maqui and Omega 3: effects on lipid profile, oxidative stress levels and psycho-physical items in human subjects

Attilio Cavezzi , Roberto Corsi, Galya Dimitrova, Roberto Colucci, Stefania Paccasassi, Valentina Quinzi, Elena Fioroni, Fausto Campana, Simone Ugo Urso, Giovanni Mosti

Attilio Cavezzi
Eurocenter Venalinfa, San Benedetto del Tronto (AP), Italy. Email: info@cavezzi.it

Roberto Corsi
Eurocenter Venalinfa

Galya Dimitrova
Eurocenter Venalinfa

Roberto Colucci
Eurocenter Venalinfa

Stefania Paccasassi
Eurocenter Venalinfa

Valentina Quinzi
Eurocenter Venalinfa

Elena Fioroni
Laboratorio Fioroni, San Benedetto del Tronto (AP), Italy

Fausto Campana

Simone Ugo Urso
Eurocenter Venalinfa

Giovanni Mosti
Casa di Cura Barbantini, Lucca, Italy
Online First: April 15, 2017 | Cite this Article
Cavezzi, A., Corsi, R., Dimitrova, G., Colucci, R., Paccasassi, S., Quinzi, V., Fioroni, E., Campana, F., Urso, S., Mosti, G. 2017. Maqui and Omega 3: effects on lipid profile, oxidative stress levels and psycho-physical items in human subjects. Discovery Phytomedicine 4(2): 26-30. DOI:10.15562/phytomedicine.2017.42

Aims: to assess short-term efficacy of supplementation with Maqui (Aristotelia Chilensis (Mol.Stuntz)), a polyphenol with antioxidant power, and EPA/DHA concerning metabolism, oxidative stress and mental/physical state.
Patients and Methods: a pilot prospective observational clinical/laboratory study was performed on 17 apparently healthy subjects (8 males and 9 females, mean age 47 years). All subjects received for two months: a) Maqui 600 mg per day and b) 360 mg of EPA and 240 mg of DHA (salmon oil) daily. At day 0 and day 60 all subjects underwent nine laboratory tests related to inflammation, metabolism (lipid profile mainly) and oxidative stress parameters. Pre-post treatment weight and BMI was calculated. A few physical and mental parameters were assessed by means of Short-Form 12 questionnaire. Statistical analysis was applied to the resulting data through Wilcoxon test and t-paired test.
Results: laboratory results before and after Maqui + EPA/DHA supplementation were respectively (mean and p-value for the comparison): total cholesterol 228.8/199.8 mg/dl, p=0.23; low density lipoproteins 127.4/122.1 mg/dl, p=0.13; high density lipoproteins 59.1/57.6 mg/dl, p=0.25; Reactive C Protein 0.18/0.09 mg/dl, p=0.32; triglycerides 106.1/91.1 mg/dl p=0.09, glycemia 92.9/92.8 mg/dl p= 0.92; total free radicals 338.0/303.6 U.Carr., p=0.002; serum anti-oxidant capacity 2075/2190 umol/l, p= 0.04; oxidized lipoproteins 641.8/553.1 uEq/l, p=0.10. SF12 physical and mental items (mean values and SD) were 51.2 (+/- 6.2) and 41.2 (+/- 3,3) at day 0 and 54.6 (+/- 11.6) and 47.2 (+/- 9.7) at day 60 respectively. One case of transient constipation was recorded.
Conclusions: daily supplementation with Maqui 600 mg + Omega 3 fatty acids (EPA 360 mg + DHA 240 mg) in apparently healthy middle-aged subjects resulted in a statistically significant improvement of oxidative stress parameters. An overall (non statistically significant) improvement of dysmetabolism biomarkers was achieved. Mental and physical parameters have mildly improved.
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