ORIGINAL ARTICLE

New insight in neuropharmacological activities of Dioscorea alata

K. M. Ruhul Amin, Md. Mamun Or Rashid , Md. Giash Uddin, Tusnova Sharmin

K. M. Ruhul Amin
Noakhali Science and Technology Uiversity, Sonapur, Noakhali-3814, Bangladesh

Md. Mamun Or Rashid
Noakhali Science and Technology Uiversity, Sonapur, Noakhali-3814, Bangladesh. Email: mamun_nstu@yahoo.com

Md. Giash Uddin
Noakhali Science and Technology University, Sonapur, Noakhali-3814, Bangladesh

Tusnova Sharmin
Noakhali Science and Technology University, Sonapur, Noakhali-3814, Bangladesh.
Online First: January 15, 2018 | Cite this Article
Amin, K., Rashid, M., Uddin, M., Sharmin, T. 2018. New insight in neuropharmacological activities of Dioscorea alata. Discovery Phytomedicine 5(1): 1-6. DOI:10.15562/phytomedicine.2018.52


The purpose of our present study was to evaluate the neuropharmacological activities of the methanolic extract of Dioscorea alata tuber using mice model. Neuropharmacological activities of this extract were determined using standard behavioral mice models like- elevated plus maze and hole board test for anxiolytic activity; open field, hole cross, tail suspension and force swimming test for exploratory activities of mice. Our result showed that D. alata extract possesses significant dose dependent indicative of neophilia in elevated plus maze and hole board test. The time spent in open arm was 28±0.95 seconds (for 250 mg/kg extract feeding group) and 82±2.02 seconds (for 500 mg/kg extract feeding group); whereas the control groups spent time was 19.0±2.17 seconds. In addition, the crude also showed a significant dose dependent suppression of exploratory activity by decreasing serotonin level of swiss albino mice in open field, hole cross, tail suspension and force swimming test respectively at both doses (p<0.001). The action on inhibition of serotonin and noradrenalin may play important role in motor activity. Finally, it can be concluded that the methanolic extract of D. alata showed significant antidepressant and anxiolytic activities, and it might be a potential source of natural antidepressant and anxiolytic agents.
No Supplementary Material available for this article.
Article Views      : 0
PDF Downloads : 0