ORIGINAL ARTICLE

ANTIOXIDANT AND ANTIULCER ACTIVITIES OF ETHANOL LEAF EXTRACT AND FRACTIONS OF SOLANUM ANOMALUM

Jude E Okokon , Emmanuel E. Nyong, Paul S. Thomas, ANWANGA E UDOH

Jude E Okokon
Dept of Pharmacology and Toxicology,University Of UyoUyo,Uyo, Nigrria. Email: judeefiom@yahoo.com

Emmanuel E. Nyong
Dept of Pharmacognosy and Natural Medicine, Univers ity of Uyo, Uyo, Nigeria

Paul S. Thomas
Dept of Pharmacognosy and Natural Medicine, university of Uyo, Uyo, Nigeria

ANWANGA E UDOH
DEPT OF PHARMACOLOGY AND TOXICOLOGY, UNIVERSITY OF UYO, UYO, NIGERIA
Online First: April 15, 2019 | Cite this Article
Okokon, J., Nyong, E., Thomas, P., UDOH, A. 2019. ANTIOXIDANT AND ANTIULCER ACTIVITIES OF ETHANOL LEAF EXTRACT AND FRACTIONS OF SOLANUM ANOMALUM. Discovery Phytomedicine 6(2). DOI:10.15562/phytomedicine.2019.79


Solanum anomalum leaf is used in Ibibio traditional medicine for the treatment of various ailments including diabetes mellitus, malaria and ulcer. The ethanol leaf extract and fractions of Solanum anomalum were investigated for in vitro antioxidant activity using various models; 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, Ferric Reducing Power assay (FRAP) and Nitric oxide (NO) scavenging assay and antiulcer activity using indomethacin, ethanol and histamine-induced ulcer models in rats. The leaf extract and fractions exhibited significant antioxidant activity with the hexane and dichloromethane fractions demonstrating higher antioxidant potentials. The leaf extract (70-210 mg/kg) was found to significantly (p<0.05 -0.001) inhibit ulcers induced by indomethacin, ethanol and histamine in a dose-dependent fashion. These results suggest that the leaf extract of Solanum anomalum possess  antioxidant and antiulcerogenic potentials which are due to the activities of the phytochemical constituents.

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