RESEARCH REVIEW

Tephrosia purpurea (L.) Pers. (Sarphuka, Wild Indigo): An important drug of Unani system of medicine

Mushir Ansari , Nasreen Jahan

Mushir Ansari
. Email: dr.ansarimushir98@gmail.com

Nasreen Jahan
National Institute of Unani medicine
Online First: April 15, 2019 | Cite this Article
Ansari, M., Jahan, N. 2019. Tephrosia purpurea (L.) Pers. (Sarphuka, Wild Indigo): An important drug of Unani system of medicine. Discovery Phytomedicine 6(2). DOI:10.15562/phytomedicine.2019.80


Tephrosia purpurea is a species of flowering plant in the pea family, Fabaceae, widespread in the Indian subcontinent. In Unani system of medicine it is either used as a single drug or as an ingredient in many Unani formulations which are use in the treatment of various ailments of the body. In the present manuscript the information available about this drug in Unani literature, phytochemical and pharmacological investigations carried out upto August 2018 are summarized. Sarphuka is a blood purifier, diuretic, digestive, laxative, resolvent, antidote etc. It is used in the treatment of syphilis, gonorrhea, leprosy, pruritus, inflammation, hemorrhoids and skin diseases. Pharmacological and clinical investigation of Tephrosia purpurea revealed anti-inflammatory, analgesic, hepatoprotective, immunomodulatory anti-diabetic, anti-bacterial, antioxidant, antileishmanial, anti-carcinogenic and anti-lipidperoxidative activities. 

References

Unani System of Medicine The Science of Health and Healing. Ministry of AYUSH, Government of India, New Delhi retrieved from; www.indianmedicine.nic.in.2016.

Sujatha S, Renuga B. Integrated imminent wide scientific potential from tropical weedy medicinal plant of Tephrosia purpurea (Linn.) Pers. An overview. World journal of pharmaceutical research. 3(4); 119-137.

T. Rathakrishnan. Traditional Agricultural Practices: Applications & Technical Implementations. By.2009.p 208. New India publishing agency. New Delhi.

Ghani MN. Khazain-ul-Advia (Musawwar Edition). (YNM): New Delhi: Idara Kitab-ush-Shifa; 797

Ashraf, M.Makhzanul Mufradat Mae Murakkabat Wa Khwasul Advia. (YNM): Rizvi Kutub Khana, Urdu Bazar, Lahore, Pakistan, pp. 144.

Anonymous, 1986. Qarabadeen Majeedi., Ninth ed. In: Proceedings of the All India Unani Tibbi Conference, New Delhi. 1–415.

Nadkarni KM, Indian Materia Medica, Vol I. 1986; Bombay Popular Prakashan, Bombay;361-2.

Palbag S, Bijay Kr. Dey, Narendra Kumar Singh. Ethnopharmacology, phytochemistry and pharmacology of Tephrosia purpurea. Chinese Journal of Natural Medicines. 2014; 12(1): 1-7.

Negi K, Aminuddin, Khan MSY. Leaf Architecture of a Unani drug ‘Sarphuka’ (Tephrosia purpurea (L.) Pers.) : An Aid to Identification. Hippocratic J. Unani Med. 2012 ; 7(1): 59-70,

The Wealth of India, In: A Dictionary of Indian Raw Materials and Industrial Product. vol. X. New Delhi, India: Publication and Information Directorate, CSIR. 1976, 151-6.

Billore KV, Yelne MB, Dennis TJ. Database on Medicinal Plants Used in Ayurveda, . Vol. 6, Central Council for Research in Ayurveda & Siddha, India: New Delhi, 2004:358-373.

Anonymous: Quality Standards of Indian Medicinal Plants [M] Vol 1. 2003. Indian Council of Medical Research, India: New Delhi: 187-197.

Kaviraj Atrideva Gupta. Ashataanga Samgraha. Krishnadas Academy Varanasi, Reprint 2002, Uttarsthana;46/29:377.

Kabeeruddin HM. Ilmul Advia Nafisi. New Delhi: Ejaz Publications; 2007

Lubhaya Ram. Goswami Bayan-ul-Advia, Part I, 1977; Goswami Pharmacy; Delhi: 310.

Lughatul kabeer Lughatul advia. Hakeem Mohammed Kabiruddin, 1920. Matbuaa jayyed press, Delhi.

Kitabul Mufaradat al Maruf ba Khawasul Advia. Third edition. Hakeem Muzaffar Husain Aewan, 1960. Shaikh Gulam Ali and sons publication, Lahore.

Ahsan, MT, Zafar S, Temperament of drugs in Unani medicine: a critical analysis. Hamdard Med. 2012; 55: 73–78.

Makbul SAA, Jahan N, Ahmad G. Hajrul yahood (Lapis judaicus): An important mineral drug of Unani system of medicine for the management of urolithiasis. Journal of Ethnopharmacology. 2018; 222: 165–170.

Ibn Sina AAHIA. Al Qanoon Fit Tib. New Delhi: Idara Kitab Al Shifa, 2010

Ansari AP, Ahmed NZ, Wadud A, Anwar N, Sheeraz M, Ahmed H. A concept of Muzir and Muslah of Unani drugs with scientific evidences: an overview. Journal of Research in Unani medicine. 2018; 7(1):70-77.

Azmi, W. Abdal Advia ka ilmi sarmaya aur ahd-e-hazir me uski ahmiyat. Jahan- e- tibb (Urdu). 1999–2000; 2–3: 31–36.

Al Razi, Z.,. Kitab Al Abdal, Third ed. 2000. Central Council for Research in Unani Medicine (Urdu), Ministry of Health and Family Welfare, Govt. of India, New Delhi, pp. 1–96.

Gupta RK, Krishnamurti M, Parthasarathi J. Purpurin: A new flavanone from Tephrosia purpurea seeds. Phytochemistry.1980; 19(6): 1264

Sinha B, Natu AA, Nanavati DD. Prenylated flavonoids from Tephrosia purpurea seeds. Phytochemistry. 1982; 21(6): 1468-1470.

Mohamed EFH, Mohamed H, Abd ER, Nagashima F, Asakawa Y, Pare PW. Rare prenylated flavonoids from Tephrosia purpurea. Phytochemistry.2009; 70(12): 1472-1474

Chang LC, Chavez D, Song LL, Farnsworth NR, Pezzuto JM, Kinghorn AD. Absolute configuration of novel bioactive flavonoids from Tephrosia purpurea. Org Lett.2000; 2(4): 515-518.

Khalafalah AK , Yousef AH, Esmail AM, . Abdelrazik MH, Hegazy MEF, Mohamed AHM. Chemical constituents of Tephrosia purpurea. Pharmacognosy Res. 2010; 2(2): 72–75.

Saleem M, Ahmed S, Alam A, Sultana S. Tephrosia purpurea alleviates phorbol ester-induced tumor promotion response inmurine skin. Pharmacol Res. 2001; 43(2): 135-144.

Khan N, Sharma S, Alam A, Saleem M, Sultana S. Tephrosia purpurea meliorates N-diethyl nitrosamine and potassium bromate-mediated renal oxidative stress and toxicity in Wistar rats. Pharmacol Toxicol. 2001; 88(6): 294-299.

Despande SS, Shah GB, Parmar NS. Antiulcer activity of Tephrosia purpurea in rats. Indian J Pharmacol. 2003; 35(3): 168-172.

Sonawane LL, Nirmal SA, Rub RA. Effect of Tephrosia purpurea roots extract on acetic acid-induced colitis in mice. Lat Am J Pharm. 2011; 30(2): 402-406.

Soni KK, Khare ML, Saxena RC. Spasmolytic activity of a herbal drug isolated from Tephrosia purpurea in guinea pigs. Ancient science of life.2004; 23(4):59.

Janbaz KH, Qadir MI, Jan A,Gilani AH. Anti-diarrheal activity of methanolic extract of Tephrosia purpurea. Acta. Pol. Pharm. (2013). 79(2), 345-347.

Sharma P , Rastogi S , Bhatnagar S, Srivastava JK, Dube A , Guru PY, et al Antileishmanial action of Tephrosia purpurea linn, extract and its fractions against experimental visceral leishmaniasis. Drug. Dev. Res. 2003; 60:285–293.

Pavana PB, Sethupathy SA, Santha KA, Manoharan S. Effect of Tephrosia purpurea aqueous seed extract on blood glucose and antioxidant enzyme activity in streptozocin-induced diabetic rat. Afr J Trad Compl Alt Med, 2009, 6(1): 78-86.

Pamu P, Manoharan S, Sethupathy S. Beneficial Effects of Tephrosia purpurea Ethanolic Seed Extract on Lipids and Membrane Bound Enzymes in Experimental Diabetic Rats. J Young Pharm. 2017;9(4):550-4.

Patel A, Patel A, Patel NM. In vitro antioxidant capacity ofleaves of Tephrosia purpurea Linn. Int J Pharm Sci Res.2010;1(1): 66-7.

Asuntha G, Prasannaraju Y, Sujatha D, Kvsrg P. Assessment of effect of ethanolic extract of Tephrosia purpurea (L.) Pers. on lithium-pilocarpine-induced status epilepticus and oxidative stress in Wistar rats. Braz J Pharmacog. 2010; 20(5): 767-772.

Swathi D, Sujatha D, Bharathi K, Kvsrg P. Antilithiatic activity of the aqueous extract of the roots of Tephrosia purpurea Linn. Pharmacog Mag. 2008; 4(16): 206-211.

Chaudhari TB, Tambe DA, Chaudhari SR. Phytopharmacology of Tephrosia purpurea Pers. (Fabaceae), IJPI’s J of Pharmacogno and Herbal Formulations. 2012;2(8):1-13.

Lodhi S, Pawar RS, Jain AP, et al. Wound healing potential of T. purpurea (Linn.) Pers. in rats. J Ethnopharmacol. 2006; 108(2): 204-210.

Kokila AP, Patel AN, Prajapati SN. Preliminary phytochemical screening and study of antiviral activity and antibacterial activity of Tephrosia purpurea flower. Life Sci Leaf. 2010;1(1): 7-13.

Rajal S, Parmar S, Bhatt P, et al. Evaluation of hepato protective activity of ethanolic extract of T. purpurea. Pharmacologyonline. 2011; 3: 188-194.

Gora RH, Baxla SL, Kerketta P, Patnaik S, Roy BK. Hepatoprotective activity of Tephrosia purpurea against arsenic induced toxicity in rats. Indian J Pharmacol 2014; 46; 197-200.

Khatria A, Gargb A, Shyam S. Agrawal C. Evaluation of Hepatoprotective Activity of Aerial Parts of Tephrosia Purpurea and Stem Bark of Tecomella Undulate, Journal of Ethnopharmacology. 2009; 122 : 1–5.

Gulecha V, Sivakumar T, Upaganlawar A, Khandare R, Upasani C. Tephrosia purpurea Linn leaves attenuate pain and inflammation in experimental animals. Int J Nutr Pharmacol Neurol Dis. 2011;1:146-51

Anbarasi A, Vidhya R. Evaluation of In Vitro Anti-Inflammatory Activity of Tephrosia purpurea (Seed). Asian Journal of Pharmaceutical Research. 2015; 5(2): 83-89.

Khan NA. In vitro antimicrobial activity of triterpenoid saponins from Tephrosia purpurea seeds extract. Eur J Chem. 2011; 2(2): 189‐192.

Venkatraman SP, Krushnarajan D, Mannivannan R. Phytochemical evaluation and antimicrobial activity of Tephrosia purpurea. Imp J Pharm Cosmetol. 2011;1: 8-16.

Kumar AS, Amudha P, Kannan CS. Evaluation of anxyolytic activity of hydroalcoholic extract of Tephrosia purpurea on Swiss albino mice. Int J Pharm Sci Res. 2011; 2:1262-1269.

Lalluvai GP, Mittal D. Mast cell stabilizing potential of the ethanolic extract of Tephrosia purpurea in management of asthma. Int J Res Ayur Pharm. 2011; 2(4): 1308-1312.

Subadhra S, Kanacharalapalli VR, Ravindran Vk, Pare SK, Chintalla S, Thatipally R. Comparative toxicity assessment of three classes of three Tephrosia species on Artimiasalina and animal cell lines. J Nat Pharm. 2011;2(3): 143-148

Hussain T, Siddiqui HH, Fareed S, Vijayakumar M,Rao CV. Chemopreventive evaluation of Tephrosia purpurea against N-nitroso diethylamine-induced hepatocarcinogenesis in Wistar rats. J Pharm Pharmacol. 2012; 64(8): 1195-205.

Gulecha V, Sivakuma T. Anticancer activity of Tephrosia purpurea and Ficus religiosa using MCF 7 cell lines. Asian Pac J Trop Med.2011; 4(7): 526-529

Muralidhar A, Somasekhar A, Sumanjali A, Kumar BP, Lakshmi B. Anticancer activity of Tephrosia purpurea root extracts against Ehrlich Ascites Carcinoma (EAC) cells in swiss albino mice Pelagia Research Library. 2014;5(2):81-87

Wanyama PJ, Fredrick LE, Hoseah MA. Terpurinflavone: anantiplasmodial flavone from the stem of Tephrosia purpurea. Phytochem Lett. 2011; 4(2): 176-178.

Atilaw Y, Muiva-Mutisya L, Ndakala A, Akala HM, Yeda R, Wu YU, et al. Four Prenyl flavone Derivatives with Antiplasmodial Activities from the Stem of Tephrosia purpurea subsp. Leptostachya. Molecules. 2017; 22:1514.

Manjula R, Anand TJ, Sudhir M, Ali SL, Kishore CN. Evaluation of Anti Pyretic Activity of Tephrosia purpurea LINN in Albino Rats R. American Journal of Phytomedicine and Clinical Therapeutics. 2013; 1(6): 467-470

Valli G, Vasanthi A, Vijayalakshmi R ,ThangaThirupathi A. Antipyretic and anti-inflammatory activities of Tephrosia purpurea root extracts. IJPRD.2011; 3(6):211-217.

Mustak S, Comparative study of Tephrosia purpurea (Linn) leaves and Lovastatin on cholesterol level of hyperlipidemic wistar rats. IOSR Journal of Pharmacy and Biological Sciences. 2012; 1(2):25-30.

Manjula RR, Spandana U, Anand TJ, Sudheer M. In vitro anthelmintic activity of aqueous and methanolic leaf extract of Tephrosia purpurea Linn. International journal of research in pharmacy and chemistry 2013; 3(1):12-14.


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