ORIGINAL ARTICLE

Assessment of Antidiarrheal Action of the Methanolic Extract of Brassica nigra Flower in Swiss Albino Mice

Mohammad Sarowar Uddin, Md. Nazmul Huda, Sakib Mosharraf, Md. Shalahuddin Millat

Mohammad Sarowar Uddin
Lecturer, Department of Pharmacy, Noakhali Science and Technology University

Md. Nazmul Huda
Postgraduate Student, Department of Pharmacy, Noakhali Science and Technology University

Sakib Mosharraf
Postgraduate Student, Department of Pharmacy, Noakhali Science and Technology University

Md. Shalahuddin Millat
Lecturer, Department of Pharmacy, Noakhali Science and Technology University. Email: millat404pharma@gmail.com
Online First: April 15, 2019 | Cite this Article
Uddin, M., Huda, M., Mosharraf, S., Millat, M. 2019. Assessment of Antidiarrheal Action of the Methanolic Extract of Brassica nigra Flower in Swiss Albino Mice. Discovery Phytomedicine 6(2). DOI:10.15562/phytomedicine.2019.84


The purpose of the present study was to evaluate the antidiarrheal activity of methanol extracts of Brassica nigra flower using castor oil – induced diarrhoea and gastrointestinal motility test using charcoal meal method. The methanolic extract was initially fractioned which was assayed for its effect in castor oil – induced diarrhoea at different doses (200 and 400 mg/kg body weight) followed by its evaluation on the peristaltic movements in charcoal meal test using loperamide as a reference drug. The results of the present study indicated that, administration of the various fractions of methanolic extract of Brassica nigra induced dose-dependent percentages of inhibition of diarrhoea. The antidiarrheal potential of this plant might be due to its high contents of flavonoids and tannins. It could be claimed that, the remarkable antidiarrheal activity of Brassica nigra flower support to its utility in a wide range of remedies of diarrhoea.

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