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Objectives: This study was conducted to investigate the antiemetic, antimicrobial and anti-radical properties of two plants of Apiaceae family named Foeniculum vulgare and Centella asiatica. 

Materials and Methods: The antiemetic assay was carried out by using chick emetic model with minor modifications by calculating the mean decrease in the number of retching. The antimicrobial activity of the crude extract was performed by Disc Diffusion method. The anti-radical activity was determined by the 2, 2-diphenyl-2-picrylhydrazyl hydrate (DPPH) method.

Results: The anti-emetic activity of the selected two plants on young chicks revealed that these extracts have a less anti-emetic effect. The group of chicks treated with Chlorpromazine was found to have 38.4 retches as compared to the 60.4 retches of the control group, thus Chlorpromazine reduced the retches by 36.96%. The chickens treated with Foeniculum vulgare and Centella asiatica extracts inhibited the retches up to 7.01% and 15.67% accordingly. The minimum antimicrobial effect was found in these two crude extracts. Both of these extracts did not appear potent in terms of both zones of inhibition and spectrum of activity. In anti-radical activity test, the Foeniculum vulgare and Centella asiatica showed moderate free radical scavenging activity with IC50 value 240.39 μg/ml and 241.71% respectively while compared to that of the reference standard ascorbic acid.

Conclusion: The selected two plants of Apiaceae family possess less anti-emetic, minimum anti-microbial and moderate anti-radical activities.


  1. Cartea ME, Francisco M, Soengas P, Velasco P. Phenolic compounds in Brassica vegetables. Molecules. 2011; 16(1): 251-280.
  2. Duthie SJ, Ma A, Ross MA, Collins AR. Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes. Cancer Res., 1996; 56:1291–1295.
  3. Tanna MTH, Nath AK, Amin MN, Ibrahim M, Chowdhury MI, Mukul MEH, et al. Evaluation of antioxidants, membrane stabilizing, cytotoxic and anthelmintic activity with phytochemical screening of Chromolaena odorata: A medicinal shrub. Int J Pharm, 2016; 6(1):53-61.
  4. Chesney JDM, Venkataraman SK, Henry JT. Plant natural products: back to the future or into extinction. Phytochemistry, 2007; 68(14):2015-22.
  5. Dewan SMR, Amin MN, Adnan T, Uddin SMN, Shahid-Ud-Daula AFM, Sarwar G, et al. Investigation of analgesic potential and in vitro antioxidant activity of two plants of Asteraceae family growing in Bangladesh. Journal of Pharmacy Research, 2013, 6(6): 599-603.
  6. Uddin SMN, Amin MN, Shahid-Ud-Daula AFM, Hossain H, Haque MM, Rahman MS et al. Phytochemical screening and study of antioxidant and analgesic potentials of ethanolic extract of Stephania japonica Linn. Journal of Medicinal Plant Resrearch, 2014; 8(37): 1127-1133.
  7. Fake AZ, Scalley RD, Bailey AG. Practical selection of antiemetics. Am Fam physician, 2004; 69, 1169–1174.
  8. Sajib AI, Dewan SMR, Das A, Sarwar MS, Sarkar RC, Ahmed M, et al. In vitro antimicrobial activity study and invivo antiemetic, antinociceptive activity evaluation of leaves extract of Erioglossum rubiginosum using experimental animal model. Oriental Pharmacy and Experimental Medicine, 2015; 15:135-140.
  9. Balouiri M, Sadiki M, Ibnsouda SK. Methods for invitro evaluating antimicrobial activity: A review,†Journal of Pharmaceutical Analysis, 2016; 6(2): 71-79.
  10. Nascimento GF, Gislene J,.Locatelli PC, Silva GL. Antibacterial activity of plant extracts and phytochemicals on antibiotic-resistant bacteria. Braz. J. Microbiol.2000; 31(4): 247-256.
  11. Raju GS, Moghal MMR, Dewan SMR, Amin MN, Billah MM. Characterization of phytoconstituents and evaluation of total phenolic content, anthelmintic, and antimicrobial activities of Solanum violaceum Ortega. Avicenna Journal of Phytomedicine. 2013, 3(4): 313-320.
  12. Davies KJ. Oxidative Stress: The Paradoxof Aerobic Life. Biochemical Society Symposium, 1995; 61: 1-31.
  13. Mustafa TM, Sura MK, kadir MNJA, Sarah IA. Free radical and human health. International journal of innovation sciences and research, 2015; 4(6): 218-223.
  14. Halliwell B. How to characterize an antioxidant-Anupdate. Biochem Soc Symp, 1995; 61:73–101.
  15. Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl. Acad.Sci., 1993; 90:7915–7922.
  16. Amiri MS, JoharchI MR. Ethnobotanical knowledge of Apiaceae family in Iran: A review. Avicenna J Phytomed. 2016; 6(6): 621–635.
  17. Akita Y, Yang Y, Kawai T, Kinoshita K, Koyama K, Takahashi K. New assay method for surveying antiemetic compounds from natural sources. Nat Prod Sci. 1998; 4:72–77.
  18. Brand-Williams W, Cuvelier M and Berset C. Use of free radical method to evaluate antioxidant activity, LWT-Food Science and Technology. 1995; 28 (1): 25-30.
  19. Pittella F, Dutra RC, Junior DD, Lopes MT, Barbosa NR. Antioxidant and cytotoxic activities of Centella asiatica (L) Urb. Int J Mol Sci. 2009; 10(9):3713-21.
  20. Ahmad BS, Talou T, Saad Z, Hijazi A, Cerny M, Kanaan H, et al. Fennel oil and by-products seed characterization and their potential applications. Industrial Crops & Products. 2018;111: 92-98.
  21. Baul S, Amin MN, Hussain MS, Mukul MEH, Millat MS, Rashed MSU, et al. Phytochemical Nature and Pharmacological Evaluation of Chloroform Extract of Pandanus fascicularis L. (Fruits) An in vivo Study. Journal of Bioanalysis & Biomedicine 2017, 9(4): 223-228.

How to Cite

Mohammad, N. (2019). Determination of antiemetic, antimicrobial and anti-radical properties of two plants of Apiaceae family growing in Bangladesh. Discovery Phytomedicine - Journal of Natural Products Research and Ethnopharmacology, 6(2).




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