ORIGINAL ARTICLE

ANTIMALARIAL AND ANTIPYRETIC ACTIVITIES OF CORNSILK EXTRACT AND FRACTIONS OF ZEA MAYS

Jude Efiom Okokon , JOHN A UDOBANG, UTIBE O. BASSEY, HEMANT KUMAR BANKEHDE

Jude Efiom Okokon
Dept of Pharmacology and Toxicology,University Of UyoUyo,Uyo, Nigrria. Email: judeefiom@yahoo.com

JOHN A UDOBANG
UNIVERSITY OF UYO, UYO, NIGERIA

UTIBE O. BASSEY
UNIVERSITY OF UYO

HEMANT KUMAR BANKEHDE
Institute of Pharmacy, Vikram University , Ujjain, MP, India
Online First: October 15, 2019 | Cite this Article
Okokon, J., UDOBANG, J., BASSEY, U., BANKEHDE, H. 2019. ANTIMALARIAL AND ANTIPYRETIC ACTIVITIES OF CORNSILK EXTRACT AND FRACTIONS OF ZEA MAYS. Discovery Phytomedicine 6(4). DOI:10.15562/phytomedicine.2019.90


 Antiplasmodial and antipyretic activities of Z. mays L. (Family- Poacae)  cornsilk extract and fractions, was carried out to ascertain the folkloric claim of its antimalarial and antipyretic activities. The cornsilk extract (170–510 mg/kg) and fractions  (hexane, dichloromethane, ethyl acetate and methanol; 340 mg/kg) were investigated for suppressive, prophylactic, and curative antiplasmodial activities against chloroquine-sensitive Plasmodium berghei infections in Swiss albino mice and for antipyretic activity against D-amphetamine, 2,4-dinitrophenol and yeast-induced pyrexia. chloroquine (5 mg/kg) and pyrimethamine (1.2 mg/kg) were used as positive controls for antiplasmodial models and Acetyl salicylic acid, ASA,(100 mg/kg) was used as standard for antipyretic models. Thin films made from tail blood of each mouse were used to assess the level of parasitaemia of the mice. The extract/fractions progressively reduced parasitaemia induced by chloroquine-sensitive P.  berghei  infection  in  prophylactic  (46.16–86.80%),  suppressive  (48.59–71.95%), and curative (22.4–82.34%) models in mice. These reductions were statistically significant (p<0.01–0.001). They also improved significantly (p<0.01–0.001) the mean survival time (MST) from 18.91 to 23.66 d in suppressive, 17.33 to 28.00 in prophylactic and 20.25 to 26.75 d in curative models  relative to control (13.75 d). The activities of extract/fractions were comparable to that of the standard drugs used (pyrimethamine) in prophylactic model only.  The extract exerted prominent inhibition of pyrexia on amphetamine, dinitrophenol and yeast-induced pyrexia (5 h). Inhibition was significant (p<0.05–0.001) from 2 to 5 h post- administration of extract and in a dose-dependent fashion. The plant may possess antiplasmodial and antipyretic effects which may in part be mediated through the chemical constituents of the plant.

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