In the past few years several developments in medications have been made for the better treatment of certain diseases like Breast Cancer, Alzheimer’s disease, Tuberculosis, Obesity and Malaria. Phytochemicals possessing various medicinal properties have opened up the door to discover or design novel drug against these diseases. Syringic acid is such a natural compound found in many plants with a vast range of therapeutic potentials against several diseases. The present study aims to reveal Syringic acid as a potent inhibitor against Breast Cancer, Alzheimer’s disease, Tuberculosis, Obesity and Malaria comparing to the standard drugs of each disease. Molecular docking of syringic acid with critical proteins associated with the diseases was done using Schrödinger Maestro (v11.1). QikProp module of Schrödinger Maestro was used for ADME prediction and the toxicity of the ligand was evaluated by ProTox online databases. Syringic acid was found to exhibit acceptable ADME properties with no carcinogenicity and mutagenicity. Molecular docking result also showed higher scores compared to the commercially available standard drugs against four out of five diseases. The best docking scores were found against Breast cancer, Alzheimer’s disease, Obesity and Malaria which are -6.801 kcal/mol, -5.285 kcal/mol, -5.491 kcal/mol and -4.141 kcal/mol respectively. Syringic acid can be a stronger inhibitory potential agent against selected diseases than the standard drugs. Further clinical studies are required to consider syringic acid as an effective candidate drug for the better treatment of the mentioned diseases.

Punica granatum L. has proven to possess aphrodisiacs effects in the management of male sexual disorder. There being no scientific validation of these claims, Punica granatum fruit extract was investigated for its aphrodisiac activity in male rats.

Fifty (50) adult male and female albino rats of Wistar strain weighing 250-350 g and 200-250g respectively were used in this study. The pomegranate fruit extract was orally administered (500, 1000 and 1500 mg/kg) to different groups of male rats on a once-daily regime for seven (7) days.

Oral administration of Punica granatum L. fruit extract at the dose of 1500 mg/kg produced a significant increase of sexual activity in male rats. It caused a significant increase in Mounting Frequency, Intromission Frequency, Intromission Latency and caused a significant reduction in Mounting Latency and Post Ejaculatory Intervals. It also significantly increased Mounting Frequency with Penile anaesthetization as well as frequencies of Erection, Quick and Flips, Long Flips and the aggregate of penile reflexes with penile stimulation. In addition, the extract was also observed to be devoid of any adverse effects and acute toxicity.

The resultant significant and sustained increase in the sexual activity of normal male rats without any conspicuous adverse effects indicate that Punica granatum certainly has aphrodisiac activity particularly at the dose of 1500 mg/kg and lends support to the traditional claim.

Plant-mediated synthesis is gaining acceptance in many fields i.e. biology and pharmaceutical fields. This aim of this study is synthesizing Ag nanoparticles using air-dried leaves of two (2) neglected vegetables i.e.  Celosia trigyna and Solanum nigrum.  Ultraviolet–visible spectroscopy, fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM) were used to characterize the formation of silver nanoparticles (AgNPs). The anti-inflammatory properties of these AgNPs were evaluated using Cell Stabilization Membrane (CSM) and lipoxidase assays, their antioxidant activity were established on DPPH and ABTS+ assays. The positive control employed are indomethacin and ascorbic acid for these activities. Nanoparticles synthesized were labelled for Celosia trigyna (CT-AgNPs) and Solanum nigrum (SN-AgNPs) were noticed through visual color change. The UV–Vis spectra of the synthesized nanoparticles displayed absorption bands at around 360-440 nm, which is a characteristic band for Ag and FTIR displayed possible functional groups responsible for Ag nanoparticles synthesized by these plants.  The SEM image of the AgNPs formed displayed were spherical in morphology. CT-AgNPs exhibited the most significant inhibitory activity against HRBC (IC₅₀: 32.2 µg/ml) while SN-AgNPs displayed the most significant inhibitory activity against lipoxygenases (IC₅₀: 32.8 µg/ml) when compared to the positive control used indomethacin (IC₅₀: 28.1 µg/ml). SN-AgNPs exhibited the most significant antioxidant effect against ABTS (IC₅₀: 11.4 µg/ml) while CT-AgNPs displayed the most significant antioxidant activity against DPPH (IC₅₀: 4.6 µg/ml) when compared to the positive control used ascorbic acid (IC₅₀: 4.7 µg/ml). This work showed that the synthesized AgNPs from non-cultivated vegetable can find relevance and application in health, drugs, food and environmental science.